What are Microbicides
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What is the MDP?

The Microbicides Development Programme (MDP) is a partnership set up:
  1. to determine the scientific mechanisms underlying the activity of microbicidal agents;
  2. to conduct pre-clinical evaluation of potential microbicides;
  3. to undertake Phase I and Phase II (if appropriate) studies of new products and combinations in healthy female volunteers and women with HIV infection;
  4. to compare different products and formulations in healthy female volunteers in terms of their cervico-vaginal distribution and retention by imaging;
  5. to undertake feasibility studies and Phase II microbicide trials as a prelude to Phase III studies;
  6. to undertake in Africa a multinational Phase III, randomised, double blind, placebo controlled trial of candidate compounds;
  7. to address issues raised by the availability of an effective microbicide in relation to their widespread introduction, through collaborations with behavioural scientists, health economists, social marketing specialists and mathematical modellers;
  8. to explore issues surrounding affordable microbicidal products for the developing world, including by developing relationships with pharmaceutical and biotech companies.

Who is involved in the MDP?

The MDP is co-ordinated jointly by the MRC Clinical Trials Unit and Imperial College at St Mary’s Hospital.

In addition to the MRC Clinical Trials Unit and Imperial College, the MDP partners are:

In addition to the MRC Clinical Trials Unit and Imperial College,
the MDP partners are:


AMREF/NIMR, Mwanza, Tanzania
Medical Research Council (South Africa), Durban, South Africa
Reproductive Health and HIV Research Unit, University of the Witwatersrand,
Johannesburg, South Africa
The Africa Centre for Health and Population Studies, South Africa
MRC/Uganda Virus Research Institute, Entebbe, Uganda
University Teaching Hospital, Lusaka, Zambia
Manhica/INS/FDC, Maputo/Manhica, Mozambique

UK and Europe

London School of Hygiene and Tropical Medicine
MRC Social and Health Public Sciences Unit, University of Glasgow
St George’s Hospital Medical School
University of Southampton
University of Barcelona
University of York
Oxford University

©2005 MDP | Microbicides Development Programme.....
Photographs on this page reproduced with thanks to Frank Herholdt and The Africa Centre website